Fermentation Vessel

Introduction

Fermentation is the biochemical synthesis of organic compounds by microorganisms. The process of growing microorganisms within an enclosed tank (fermenter) under controlled conditions of aeration, agitation, temperature, and pH. The kinetics of any fermentation, which may be measured by growth and product formation profiles, can be affected by a range of biochemical and physicochemical determinants. These include the process strain, the innoculum development regime, medium composition, medium pH, nutrient concentration and temperature.

Approach

Our testing is comprehensive and designed to satisfy the requirements of US (FDA), UK (MHRA) and European regulatory authorities.

Experience

PEV staff are experienced in fermentation technology, and have been extensively involved in all aspects of validation of fermentation vessel and bioreactors, ranging from stirred-tank reactors and gas-lift fermenters,
We also have extensive experience in engineering studies that include mixing and Scale up studies using various tools such as mathematical modelling and Oxygen transfer Coefficient (KLA).
We have also experience in carrying out Coverage test to determine the efficiency of the cleaning devices within the vessels.
We can provide operational resource and assistance with the generation of User Requirement Specifications (URS), through Factory Acceptance Testing (FAT) to Site Acceptance Tests (SAT) and Installation Qualification (IQ), Operational Qualification (OQ) and Performance Qualification (PQ).